Crest Detoxify Deep Clean toothpaste was created after years of research by Crest scientists, this toothpaste has been specially formulated to target the millions of plaque bacteria around the gum line. Crest Gum Detoxify Deep Clean uses an activated foam formula to help penetrate hard to reach areas, finding and neutralizing harmful plaque bacteria around the gum line for clinically proven healthier gums. Helps Neutralize Plaque Bacteria, Around the Gumline for 24 Hours with twice daily brushing.